1. Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance
Unweighted UniFrac principal coordinates analysis (PCoA) plot illustrating the relative degree that genotype (NOD2−/− versus WT, PCoA1: 28%) and diet (chow versus HFD, PCoA2: 16%) defined the diversity of the microbiota in the cecum. The most abundant bacterial genus are labeled and superimposed on the same PCoA plot. Each small dot is a mouse, and the size of the sphere representing a taxon is proportional to the mean relative abundance of the taxon across all samples. Bar graph showing the relative abundance of phyla from each mouse cecum, where each bar is a separate mouse. Alpha diversity represented by the Shannon index in chow‐fed (n = 6) and HFD‐fed (n = 5) WT and NOD2−/− mice. Values are mean ± SEM. Impact of diet on the Firmicutes/Bacteroidetes ratio in the cecum of chow‐fed (n = 12) and HFD‐fed (n = 10) mice. *Significantly different from chow‐fed mice, P = 0.03. An unpaired t‐test was used. Values are mean ± SEM.
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EMBO Mol Med, Volume: 7, Issue: 3, Pages: , First published: 09 February 2015, DOI: ( /emmm )