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Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased.

Published byLise Rasmussen Modified over 5 years ago

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Presentation on theme: "Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased."— Presentation transcript:

1 Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state.
Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. (A) Generation of Zic5 KO HCT116 cells by CRISPR-Cas9. (B) RNA-seq track to show the complete KO of Zic5 in C16 and C18 clones. (C) Immunofluorescence showing the cellular morphology of Zic5 WT and KO HCT116 cells by F-actin staining. (D) Hierarchical clustering analysis and corresponding heat map of differentially expressed genes in HCT116 Zic5 WT and KO cells. The color scale bar indicates the fold change ranges for the comparisons (ratios) indicated on the top of the heat map. (E) Effects of Zic5 KO on gene expression induced by three different conditions. 5-FU, 5-fluorouracil; DAPI, 4′,6-diamidino-2-phenylindole. Zibo Zhao et al. Sci Adv 2019;5:eaax0698 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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