1. GABAergic synaptic inhibition is not altered in MGB neurons of tinnitus rats.
GABAergic synaptic inhibition is not altered in MGB neurons of tinnitus rats. A, Representative traces of sIPSC recordings from MGB neurons from the Ctrl, Non-T, and Tin groups. Recordings were performed at +20 mV in the presence of 20 μm DNQX and 50 μm AP-5. Bath application of gabazine (GBZ) blocked all inhibitory GABAAR-mediated synaptic events. B, Averaged cumulative probability plots of sIPSC interevent intervals, amplitude, and half-width of MGB neurons in the Ctrl and Tin groups. Statistical analysis revealed no significant difference in these three GABAergic synaptic event parameters between the Ctrl and Tin groups (Ctrl, n = 29 cells; Tin, n = 29 cells). All recordings were contralateral to the sound exposure. Data are reported as the mean ± SEM.
Evgeny A. Sametsky et al. J. Neurosci. 2015;35:
©2015 by Society for Neuroscience