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Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice.

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Presentation on theme: "Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice."— Presentation transcript:

1 Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. (A) The histograms show the frequencies of total CD19+ B cells in peripheral tissues from WT mice or KitW-sh/W-sh mice with or without the adoptive transfer of MCs. (B and C) Representative plot images show IL-10+ CD19+ B cells (B), and histograms show the frequencies of CD5+CD19+ B cells (C) in peripheral tissues from WT mice or KitW-sh/W-sh mice with or without the adoptive transfer of MCs. (D) Ear thickness, (E) the frequency of IL-10+ B cells, and (F) the number of IL-13+ ILC2s are shown during CHS in WT or KitW-sh/W-sh mice with or without the transfer of MCs. Data are expressed as the mean ± SEM (A and C to F) and representative images (B) from two independent experiments (n ≥ 3 per group for each experiment). *P < 0.05; **P < 0.01; n.s., not significant by Student’s t test (D and F) or one-way ANOVA with post hoc Tukey’s test (C and E). BMMC, bone marrow-derived MC; PDMC, PeC-derived MC. Hyuk Soon Kim et al. Sci Adv 2019;5:eaav8152 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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