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Intranasal immunization of mice with S

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1 Intranasal immunization of mice with S
Intranasal immunization of mice with S. sonnei InvaplexAR induces protective immune responses against S. sonnei and S. flexneri 2a. Intranasal immunization of mice with S. sonnei InvaplexAR induces protective immune responses against S. sonnei and S. flexneri 2a. Mice were immunized intranasally on days 0, 14, and 28 with S. sonnei InvaplexAR, S. sonnei InvaplexNAT, or S. flexneri 2a InvaplexNAT and challenged using the pulmonary mouse model on day 49 with either S. flexneri 2a strain 2457T or S. sonnei strain Moseley. Mice were weighed on the day of challenge and each day for 14 days postchallenge. The average weight for each group was calculated, and the difference was expressed as a percentage of the change in weight from the prechallenge values. K. Ross Turbyfill et al. mSphere 2018; doi: /mSphere


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