1. Tfr cells respond better to immunization with self-antigens than with foreign antigens.
Tfr cells respond better to immunization with self-antigens than with foreign antigens. (A to C) Tfh (A) and Tfr (B) cell proportions within Tfol cells and Tfr/Tfh ratio (C) after INS (n = 6) or OVA (n = 7) immunization. (D and E) GCB cell proportions within CD19+ B cells (D) and correlation between the percentage of Tfr and GCB cells from INS-immunized (filled circles) or OVA-immunized (empty circles) mice (E). (F and G) GCB cell proportions within CD19+ B cells (F) and correlation between the percentage of Tfr and GCB cells from INS-immunized mice receiving IL-1β (empty circles) or not (filled circles) (G). (A to C and F) **P < 0.01, Mann-Whitney U test. (E and G) Each symbol represents one mouse, and the Spearman rank correlation value is shown.
Paul-Gydeon G. Ritvo et al. Sci. Immunol. 2017;2:eaan0368
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