1. Coexpression of Integrin αvβ3 and Matrix Metalloproteinase-2 (MMP-2) Coincides with MMP-2 Activation: Correlation with Melanoma Progression 
Uta B. Hofmann, Johan R. Westphal, Erwin T. Waas, Jürgen C. Becker, Dirk J. Ruiter, Goos N.P. van Muijen 
Journal of Investigative Dermatology 
Volume 115, Issue 4, Pages (October 2000)
DOI: /j x
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2. Figure 1
Expression of membrane-bound and soluble MMP-2 in human melanoma cell lines. (A) Zymography of cell lysates prepared from cultured untransfected (MV3, BLM) or mock-transfected (MV3-neo, BLM-neo), or β3-transfected (MV3-β3, BLM-β3) cells. Functionally active MMP-2 is present exclusively in the αvβ3 transfectants. SFCM was analyzed by zymography (B) and western blotting (C). Secretion of active MMP-2 is restricted to the β3-negative cell line as determined by zymography. Purified MMP-2 protein was used as controls (right lane). Position and molecular size of markers are indicated.
Journal of Investigative Dermatology  , DOI: ( /j x)
Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions