1. Patient factors that increase risk for drug-induced nephrotoxicity.
Patient factors that increase risk for drug-induced nephrotoxicity. Patients have risk factors from nonmodifiable characteristics such as age, sex, race, and the genetic makeup of immune response genes and drug metabolizing enzymes and transport pathways that enhance the nephrotoxicity of drugs. Comorbid conditions such as liver disease, heart disease, and CKD and acutely developed diseases such as intravascular volume depletion, metabolic perturbations, and AKI are also important risk factors for drug-induced nephrotoxicity.
Mark A. Perazella CJASN 2018;13:
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