1. Volume 27, Issue 11, Pages 3241-3253.e4 (June 2019)
Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization 
Daniel O’Connor, Eileen Png, Chiea Chuen Khor, Matthew D. Snape, Adrian V.S. Hill, Fiona van der Klis, Clive Hoggart, Michael Levin, Martin L. Hibberd, Andrew J. Pollard 
Cell Reports 
Volume 27, Issue 11, Pages e4 (June 2019)
DOI: /j.celrep
Copyright © 2019 The Author(s) Terms and Conditions

2. Cell Reports 2019 27, 3241-3253.e4DOI: (10.1016/j.celrep.2019.05.053)
Copyright © 2019 The Author(s) Terms and Conditions

3. Figure 1
Study Design
Cell Reports  , e4DOI: ( /j.celrep )
Copyright © 2019 The Author(s) Terms and Conditions

4. Figure 2
Manhattan Plots of p Values from Regression Analyses between SNPs and log10-Transformed Vaccine-Induced Immunological Measures
(A–D) Manhattan plots of p values from regression analyses between SNPs and log10-transformed vaccine-induced immunological measure: (A) MenC-specific IgG concentrations (n = 1,203), (B) MenC-specific SBA titers (n = 1,585), (C) PRP-specific IgG concentrations (n = 964), and (D) TT-specific IgG concentrations (n = 547). The horizontal blue line represents the level of suggestive statistical association (p < 1 × 10−5), and the horizontal red line denotes the level of genome-wide statistical significance (p < 5 × 10−8).
Cell Reports  , e4DOI: ( /j.celrep )
Copyright © 2019 The Author(s) Terms and Conditions

5. Figure 3
Circos Plot Illustrating Genes Containing SNPs Associated (p < 1 × 10−4) with One or More of Four Vaccine-Induced Serological Measures
Data are included from the discovery stage GWAS of persistence of MenC-specific IgG concentrations (n = 1,203), MenC-specific serum bactericidal titers (n = 1,585), PRP-specific IgG concentrations (n = 964), and TT-specific IgG concentrations (n = 547). Genes that are associated (p < 1 × 10−4) with more than the serological measures assessed are highlighted with links. This diagram was generated using Circos (
Cell Reports  , e4DOI: ( /j.celrep )
Copyright © 2019 The Author(s) Terms and Conditions