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Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine
Ilkka T. Harvima Journal of Investigative Dermatology Volume 128, Issue 12, Pages (December 2008) DOI: /jid Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Hypothetical model for the cellular interactions among mast cells, T cells, and keratinocytes in the uppermost dermis and basement membrane zone in inflamed skin. In these mechanisms, mast cell mediators histamine, IL-13, TNF-α, and TGF-β stimulate keratinocytes for MMP-9 expression, resulting in the degradation of the basement membrane and T-cell transmigration to the epidermis. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions
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