1. Bisphosphonate nephrotoxicity
Mark A. Perazella, Glen S. Markowitz 
Kidney International 
Volume 74, Issue 11, Pages (December 2008)
DOI: /ki
Copyright © 2008 International Society of Nephrology Terms and Conditions

2. Figure 1
Renal biopsy findings in bisphosphonate nephrotoxicity. (a) A glomerulus from a patient who had been treated with pamidronate exhibits collapsing focal segmental glomerulosclerosis with global wrinkling and retraction of the glomerular basement membrane. There is global swelling and proliferation of overlying visceral epithelial cells which contain protein resorption droplets. (Jones methenamine silver, × 400.) (b) In this example of toxic acute tubular necrosis following treatment with zoledronate proximal tubules exhibit severe degenerative changes including luminal ectasia, cytoplasmic simplification and hypereosinophilia, irregular luminal contours, extensive loss of brush border, prominent nucleoli, and focal apoptotic figures. (Hematoxylin and eosin, × 400.)
Kidney International  , DOI: ( /ki )
Copyright © 2008 International Society of Nephrology Terms and Conditions