1. Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
A, BRepresentative immunofluorescence images of aortas from 8‐week‐old Apoe−/−LmnaG609G/G609G (A) and Apoe−/−LmnaLCS/LCSSM22αCre (B) mice and their corresponding controls stained with anti‐α‐smooth muscle actin (SMA) antibody (red), endoplasmic reticulum chaperone binding‐immunoglobulin protein (BiP, white, upper panel), protein disulfide isomerase (PDI, white, middle panel), and calreticulin (white, bottom panel). Arrowheads indicate BiP‐positive cells. Scale bar: 50 μm. L, lumen; M, media; A, adventitia. C, DGraphs show quantification of BiP, PDI, and calreticulin protein expression in medial aortas from 8‐week‐old Apoe−/−LmnaG609G/G609G (C) and Apoe−/−LmnaLCS/LCSSM22αCre (D) mice relative to control mice (n = 6–9 mice for each genotype; aortic regions analyzed: aortic arch). Data information: In (C, D), data are mean ± SEM. Statistical differences were analyzed by one‐tailed unpaired t‐test with Welch's correction.
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EMBO Mol Med, Volume: 11, Issue: 4, First published: 12 March 2019, DOI: ( /emmm )