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Volume 54, Issue 6, Pages (January 1998)

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Presentation on theme: "Volume 54, Issue 6, Pages (January 1998)"— Presentation transcript:

1 Volume 54, Issue 6, Pages 1879-1887 (January 1998)
Growth of long bones in renal failure: Roles of hyperparathyroidism, growth hormone and calcitriol  Cheryl P. Sanchez, Isidro B. Salusky, Beatriz D. Kuizon, Patricia Abdella, Harald Jüppner, William G. Goodman  Kidney International  Volume 54, Issue 6, Pages (January 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 The total width of the growth plate cartilage (▪) and the width of the hypertrophic zone (□) in rats with normal renal function (Control) and in four groups of subtotally nephrectomized rats with mild secondary hyperparathyroidism. Nephrectomized animals received daily intraperitoneal injections of saline vehicle (Nx-C), growth hormone (Nx-GH), calcitriol (Nx-D), or both hormonal agents together (Nx-GH+D) for 10days. aP < vs. Nx-C; bP < vs. Nx-GH; cP < vs. Nx-D. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 2 Type X collagen mRNA expression in the growth plate cartilage in rats with normal renal function (Control) and in four groups of subtotally nephrectomized rats with mild secondary hyperparathyroidism. Nephrectomized animals received daily intraperitoneal injections of saline vehicle (Nx-C), growth hormone (Nx-GH), calcitriol (Nx-D), or both hormonal agents together (Nx-GH+D) for 10days. aP < vs. Control; bP < vs. Nx-C; cP < vs. Nx-C; dP < 0.01 vs. Nx-C;eP < vs. Nx-D. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 3 The total width of the growth plate cartilage (▪) and the width of the hypertrophic zone (□) in rats with normal renal function (Control) and in four groups of subtotally nephrectomized rats with advanced secondary hyperparathyroidism. Nephrectomized animals received daily intraperitoneal injections of saline vehicle (Nx-C), growth hormone (Nx-GH), calcitriol (Nx-D), or both hormonal agents together (Nx-GH+D) for 10days. aP < vs. Control; bP < vs. Nx-C; cP < vs. Nx-GH Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

5 Figure 4 PTH/PTHrP receptor mRNA expression was localized to chondrocytes in the lower proliferating zone and in the upper hypertrophic region of the growth plate cartilage in rats with normal renal function (A) and in four groups of subtotally nephrectomized rats with advanced secondary hyperparathyroidism. Nephrectomized animals received daily intraperitoneal injections of saline vehicle (B), growth hormone (C), calcitriol (D), or both hormonal agents together (E) for 10days. The expression of PTH/PTHrP receptor mRNA was markedly less in the nephrectomized animals given saline injections (B) compared to rats with normal renal function (A), however, the transcripts for PTH/PTHrP receptor were increased in animals given growth hormone (C), calcitriol (D) and both hormonal agents together (E) compared to nephrectomized control animals (B). Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

6 Figure 5 Type X collagen mRNA, type II collagen mRNA and PTH/PTHrP receptor mRNA expression in the growth plate cartilage in rats with normal renal function (Control; □) and in four groups of subtotally nephrectomized rats with advanced secondary hyperparathyroidism. Nephrectomized animals received daily intraperitoneal injections of saline vehicle (Nx-C; ▪), growth hormone (Nx-GH; ), calcitriol (Nx-D; ), or both hormonal agents together (Nx-GH+D; ) for 10days. aP < 0.05 vs. Control; bP < vs. Nx-C; cP < 0.05 vs. Nx-C; dP < 0.05 vs. Nx-GH;eP < vs. Nx-GH. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

7 Kidney International 1998 54, 1879-1887DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

8 Kidney International 1998 54, 1879-1887DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

9 Kidney International 1998 54, 1879-1887DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

10 Kidney International 1998 54, 1879-1887DOI: (10. 1046/j. 1523-1755
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


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