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Volume 71, Issue 2, Pages (January 2007)

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1 Volume 71, Issue 2, Pages 146-152 (January 2007)
Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients  E.D. Siew, L.B. Pupim, K.M. Majchrzak, A. Shintani, P.J. Flakoll, T.A. Ikizler  Kidney International  Volume 71, Issue 2, Pages (January 2007) DOI: /sj.ki Copyright © 2007 International Society of Nephrology Terms and Conditions

2 Figure 1 Scatter plots of HOMA versus skeletal muscle protein metabolism components. Simple linear regression revealed a direct relationship between HOMA and (a) skeletal muscle protein synthesis (P=0.024) and (b) skeletal muscle protein breakdown (P=0.001). (c) An inverse relationship between HOMA and net muscle protein balance was observed that approached significance (P=0.066). *Statistical significance P<0.05. Kidney International  , DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

3 Figure 2 Schematic diagram of the metabolic study day protocol. Denotes time points for blood draws and breath sample collections. Metabolic cart and plethysmography measurements were performed once during the equilibration phase. A primed-constant infusion of L-(1-13C) leucine and L-(ring-2H5) phenylalanine was maintained throughout the entire study (150min). Kidney International  , DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions

4 Figure 3 Plasma mass percent enrichment of expired CO2 and phenylalanine at study time points. Kidney International  , DOI: ( /sj.ki ) Copyright © 2007 International Society of Nephrology Terms and Conditions


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