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Differential enlargement of artery segments in response to enlarging atherosclerotic plaques
Christopher K. Zarins, M.D., Elliot Weisenberg, M.S., George Kolettis, B.A., Regina Stankunavicius, M.P.H., Seymour Glagov, M.D. Journal of Vascular Surgery Volume 7, Issue 3, Pages (March 1988) DOI: / (88) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 1 Schematic diagram illustrates location of left anterior descending coronary artery sampling sites. Section L1 was taken 1 cm from the origin of the LAD, L2 was taken one fourth of the distance from the origin of the LAD to the apex of the left ventricle, L3 was taken one half of the distance to the apex and L4 was taken three fourths of the distance to the apex. Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 2 Regression analysis of artery size (internal elastic lamina [IEL] area) and intimal plaque area. Artery size increased with increasing plaque area at each LAD level. The rate of increase in artery size at L4 was more than twice as great as at L1 (p < 0.01). Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 3 Sections from representative LADs from the quartile of arteries with the least intimal plaque and the quartile of arteries with the most intimal plaque. At L1 the most diseased artery is enlarged and there is a moderate decrease in lumen area. At L2 and L3 arterial enlargement is comparable to the increase in intimal plaque and lumen area remains normal. At L4 arterial enlargement exceeds the rate of increase in intimal plaque and lumen area is increased. Journal of Vascular Surgery 1988 7, DOI: ( / (88) ) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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