1. Tissue specificity and the human protein interaction network
The re‐use of housekeeping proteins for tissue‐specific functions. Here we use the example of neurotransmitter receptor protein complexes identified by affinity purification followed by mass spectrometry (Pocklington et al, 2006). (A) A section of the binary protein interaction network of neurotransmitter receptor complexes, with subunits marked as universally expressed (housekeeping) proteins (yellow) and non‐housekeeping (blue). The housekeeping and non‐housekeeping interaction partners of the housekeeping protein Rac1 are highlighted and labeled as examples. (B) The percentage of subunits of neurotransmitter receptor protein complexes considered as universally expressed housekeeping proteins is shown for 10 different criteria of housekeeping proteins, as described in Figure 2. Criteria10 is used in panel A. (C) The proportion of these housekeeping subunits that have been experimentally verified as essential for learning and memory in mouse models or that are implicated in psychiatric disease in humans is shown for the same 10 criteria of housekeeping proteins. Protein complex subunits, binary protein–protein interactions, and genetic data are all from Pocklington et al (2006). The network in (A) was visualized using Biolayout Express (3D) (Freeman et al, 2007).
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Mol Syst Biol, Volume: 5, Issue: 1, First published: 07 April 2009, DOI: ( /msb )