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2. Bupropion for GAD David N. Osser, MD Associate Professor of Psychiatry
Harvard Medical School
Brockton Division of the VA Boston Healthcare System
General Editor - Psychopharmacology Algorithm Project
Harvard South Shore Residency Training Program

3. Bupropion for GAD n=24 Bupropion 150-300 mg/day GAD (DSM-IV) CGI-I
HAM-A: 5.3
GAD
(DSM-IV)
CGI-I
HAM-A
Escitalopram
10-20 mg/day
n=24
HAM-A: 11.4
Bystritsky, A., Kerwin, L., Feusner, J. D., & Vapnik, T. (2008). A pilot controlled trial of bupropion XL versus escitalopram in generalized anxiety disorder. Psychopharmacology bulletin, 41(1),

4. Bupropion for GAD MDD + Anxiety Sertraline Bupropion
No differences in:
Anxiolytic and antidepressant effects
Activation and insomnia
- Trivedi, M. H., Rush, A. J., Carmody, T. J., Donahue, R. M., Bolden-Watson, C., Houser, T. L., & Metz, A. (2001). Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?. The Journal of clinical psychiatry, 62(10),
- Zimmerman, M., Posternak, M. A., Attiullah, N., Friedman, M., Boland, R. J., Baymiller, S., ... & Chelminski, I. (2005). Why isn't bupropion the most frequently prescribed antidepressant?. The Journal of clinical psychiatry, 66(5),

5. STAR*D Buspirone Augmentation for anxious patients Bupropion
9% remissions
18% remissions
First-line over SSRIs for MDD?
Trivedi, M. H., Rush, A. J., Carmody, T. J., Donahue, R. M., Bolden-Watson, C., Houser, T. L., & Metz, A. (2001). Do bupropion SR and sertraline differ in their effects on anxiety in depressed patients?. The Journal of clinical psychiatry, 62(10),
Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., ... & Warden, D. (2008). Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR* D report. American Journal of Psychiatry, 165(3),

6. Next Presentation - Benzodiazepines for GAD