1. STARmap for 3D transcriptome imaging and molecular cell typing.
STARmap for 3D transcriptome imaging and molecular cell typing. STARmap is an in situ RNA-sequencing technology that transforms intact tissue into a 3D hydrogel-tissue hybrid and measures spatially resolved single-cell transcriptomes in situ. Error- and background-reduction mechanisms are implemented at multiple layers, enabling precise RNA quantification, spatially resolved cell typing, scalability to large gene numbers, and 3D mapping of tissue architecture.
Xiao Wang et al. Science 2018;361:eaat5691
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