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Fig. 2 CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity. CAR T cell therapy is associated with cytokine release syndrome.

Published byHillary Moody Modified over 5 years ago

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Presentation on theme: "Fig. 2 CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity. CAR T cell therapy is associated with cytokine release syndrome."— Presentation transcript:

1 Fig. 2 CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity.
CAR T cell therapy is associated with cytokine release syndrome and neurotoxicity. Cytokine release syndrome has occurred with CAR T cells targeting CD19 or BCMA. When the CAR T cell engages surrogate antigens, it releases a variety of cytokines and chemokines. Macrophages and other cells of the innate immune system also become activated and contribute to the release of soluble mediators. CAR T cells are routinely observed in cerebral spinal fluid, and the cytokines may increase permeability to soluble mediators and permit increased trafficking of CAR T cells and other lymphocytes to central nervous system parenchyma. IFN, interferon; AST, aspartate aminotransferase; ALT, alanine aminotransferase. Carl H. June et al. Science 2018;359: Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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