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Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate  Shang-mian Yie, Ph.D., Hanna.

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Presentation on theme: "Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate  Shang-mian Yie, Ph.D., Hanna."— Presentation transcript:

1 Secretion of human leukocyte antigen-G by human embryos is associated with a higher in vitro fertilization pregnancy rate  Shang-mian Yie, Ph.D., Hanna Balakier, Ph.D., Gelareh Motamedi, B.R.T., Clifford L. Librach, M.D.  Fertility and Sterility  Volume 83, Issue 1, Pages (January 2005) DOI: /j.fertnstert Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Samples were grouped according to whether medium soluble HLA-G was detectable. Student's t test was used to compare average number of blastomeres per culture well (mean ± SE) between soluble HLA-G–positive and –negative groups. *Showed a significant difference between the two groups (t = −2.77, P=.0061). Fertility and Sterility  , 30-36DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Pregnancy rates were compared between HLA-G–positive and –negative groups by χ2 testing. A significant difference between two HLA-G groups was observed (χ2 = 9.09, P=.0026). N = number of cases in each group. Fertility and Sterility  , 30-36DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Pregnancy rates were compared among various groups combining soluble HLA-G detection and embryo cleavage rate. Group I: combined soluble HLA-G = 0 and number of blastomeres ≤6; group II: soluble HLA-G = 0, number of blastomeres >6; group III: HLA-G >0, number of blastomeres ≤6; and group IV: soluble HLA-G >0, number of blastomeres >6 (χ2 = 12.1, P=.007). N = number of cases in each group. Fertility and Sterility  , 30-36DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions


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