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Complete DiGeorge syndrome: Development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases  M Louise Markert, MD, PhD, Marilyn J Alexieff, BA,

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Presentation on theme: "Complete DiGeorge syndrome: Development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases  M Louise Markert, MD, PhD, Marilyn J Alexieff, BA,"— Presentation transcript:

1 Complete DiGeorge syndrome: Development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases 
M Louise Markert, MD, PhD, Marilyn J Alexieff, BA, Jie Li, BA, Marcella Sarzotti, PhD, Daniel A Ozaki, BA, Blythe H Devlin, PhD, Gregory D Sempowski, PhD, Maria E Rhein, BA, Paul Szabolcs, MD, Laura P Hale, MD, PhD, Rebecca H Buckley, MD, Katharine E Coyne, MS, Henry E Rice, MD, Samuel M Mahaffey, MD, Michael A Skinner, MD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 4, Pages (April 2004) DOI: /j.jaci

2 Fig 1 Immunoscopic evaluation of patients with atypical complete DiGeorge syndrome. The TCRBV family tested in each profile is indicated by the labels at the bottom right. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

3 Fig 2 Immune studies in patients with atypical complete DiGeorge syndrome: A, patient DIG101; B, patient DIG102; C, patient DIG104; D, patient DIG106; E, patient DIG107; F, absolute eosinophil counts; G, serum IgE levels. The 25th to 75th percentiles values for infants follow24: ALC, /mm3; CD3, /mm3; CD4, /mm3; CD8, /mm3; absolute eosinophil count, less than 350/mm3; IgE, 0-74 U/mL. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )

4 Fig 3 Skin biopsy specimen of patient DIG101 on day 326 of life: A, hematoxylin and eosin, original magnification 20×; B, CD3, original magnification 20×; C, CD8, original magnification 20×; D, S100, original magnification 20×. Note the large numbers of T cells in the dermis. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci )


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