Presentation is loading. Please wait.

Presentation is loading. Please wait.

Volume 39, Issue 3, Pages (September 2003)

Similar presentations


Presentation on theme: "Volume 39, Issue 3, Pages (September 2003)"— Presentation transcript:

1 Volume 39, Issue 3, Pages 389-396 (September 2003)
Antiviral therapy of patients with decompensated cirrhosis to prevent recurrence of hepatitis C after liver transplantation  Xavier Forns, Montserrat Garcı́a-Retortillo, Trinidad Serrano, Anna Feliu, Francisco Suarez, Manuel de la Mata, Juan Carlos Garcı́a- Valdecasas, Miquel Navasa, Antoni Rimola, Juan Rodés  Journal of Hepatology  Volume 39, Issue 3, Pages (September 2003) DOI: /S (03)

2 Fig. 1 Evolution of HCV-RNA concentrations in 30 HCV-infected patients on waiting list for liver transplantation treated with interferon and ribavirin. Viral load is expressed in IU/ml and depicted in the y axis in a logarithmic scale. A viral load value of 102 IU/ml is equivalent to a negative HCV-RNA test by a sensitive qualitative assay. Time is represented in the x axis, in weeks. Liver transplantation is represented as a vertical line (time 0). Weeks before transplantation are shown as negative values, except in patients who have not undergone liver transplantation. Dark shaded areas indicate treatment with full interferon and ribavirin dosages; light shaded areas indicate treatment at reduced doses. Non-shaded areas before transplantation indicate treatment interruption. (A) Patients who achieved virological response (HCV-RNA negativization) during therapy that persisted after liver transplantation. (B) Patients with virological response during therapy and HCV infection recurrence after transplantation. (C) Patients who did not achieve virological response during therapy. Journal of Hepatology  , DOI: ( /S (03) )

3 Fig. 1 Evolution of HCV-RNA concentrations in 30 HCV-infected patients on waiting list for liver transplantation treated with interferon and ribavirin. Viral load is expressed in IU/ml and depicted in the y axis in a logarithmic scale. A viral load value of 102 IU/ml is equivalent to a negative HCV-RNA test by a sensitive qualitative assay. Time is represented in the x axis, in weeks. Liver transplantation is represented as a vertical line (time 0). Weeks before transplantation are shown as negative values, except in patients who have not undergone liver transplantation. Dark shaded areas indicate treatment with full interferon and ribavirin dosages; light shaded areas indicate treatment at reduced doses. Non-shaded areas before transplantation indicate treatment interruption. (A) Patients who achieved virological response (HCV-RNA negativization) during therapy that persisted after liver transplantation. (B) Patients with virological response during therapy and HCV infection recurrence after transplantation. (C) Patients who did not achieve virological response during therapy. Journal of Hepatology  , DOI: ( /S (03) )

4 Fig. 2 Decrease in viral load during treatment in responders and non-responders to antiviral therapy. Viral load is expressed in IU/ml and depicted in the y axis in a logarithmic scale. Viral load decrease in each group is represented as box plot (the top and the bottom of the boxes being the 25th and 75th percentiles and the line through the middle of the box the median). Median viral load decrease was 5.45 log10 IU/ml in responders versus 1.41 log10 IU/ml in non-responders (P<0.001). Journal of Hepatology  , DOI: ( /S (03) )


Download ppt "Volume 39, Issue 3, Pages (September 2003)"

Similar presentations


Ads by Google