1. Rupture LH SURGE dissociation of cumulus mass resumption of meiosis
Increase blood flow
Edema
shift in steroid production
Stigma formation
progesterone
collagenase
Rupture
plasminogen activating factor
PGE
lysosome activity
PGF
contractions
Egg Release

2. Duration of the LH Surge
LH surge of <14 hours: No change in oocyte and granulosa cells. No support of CL
LH surge of <24 hours: Resulted in oocyte meiosis. No support of CL.
LH surge of 34 to 48 hours: Resulted in oocyte maturation and CL support.
Zelinski-Wooten et al. J Clin Endocrinol Metab 1991
Zelinski-Wooten et al. J Clin Endocrinol Metab 1992

3. Summary and Conclusions
Based on studies in hypophysectomized animals and women with hypogonadotropic hypogonadism, it is clear today that steroidogenesis is mainly supported by the synergistic action of FSH and LH

4. Summary and Conclusions
FSH is the primary hormone in the process of follicle recruitment and selection of the dominant follicle.

5. Summary and Conclusions
Human corpus luteum can be ‘rescued’ and can be function normally after 7 days of deprivation from gonadotropin stimulation in patients with hypogonadotropic hypogonadism.

6. The Role of LH in Follicular Development
Zeev Shoham, M.D.
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel
rec-hFSH