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Published byἨσαῦ Κωνσταντίνου Modified over 5 years ago
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Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2
(A) pH dependency of the state 4 respiratory rate: control ▵ and UCP2 mitochondria ▿, in basal conditions (1.6 μM fatty acid free bovine serum albumin). Solid and dashed lines refer to UCP2 mitochondria in presence of 4.8 μM palmitic acid ○ (ratio 3:1 with albumin), UCP2 mitochondria in presence of the same concentration of all‐trans retinoic acid, ●. The increase over the basal state 4 respiratory rate at pH 6.8 is plotted against pH values. Data represent the mean value ± SEM of 6–10 independent experiments. (B) Titration of the effect of all‐trans retinoic acid at pH 7.3 on the basal state 4 of control ▵, UCP1 ♦, UCP2 ●, and UCP3 □ mitochondria. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO J, Volume: 18, Issue: 21, Pages: , First published: 01 November 1999, DOI: ( /emboj/ )
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