1. Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions 
Sam Mehr, MBBS, BMedSci, FRACP, FRCPA, Eric Lee, MBBS, BSci, Peter Hsu, MBBS, FRACP, PhD, Denise Anderson, PhD, Emma de Jong, PhD, Anthony Bosco, PhD, Dianne E. Campbell, MBBS, FRACP, PhD 
Journal of Allergy and Clinical Immunology 
Volume 144, Issue 2, Pages e2 (August 2019)
DOI: /j.jaci
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2. Fig 1
A, The top 10 predicted upstream transcriptional regulators of reactive and nonreactive food responses. Upstream transcriptional regulators significantly associated with the food response for nonreactors or reactors, as well as the genes significantly different between food responses for each group, are shown. Those predicted to be activated are colored red, and those predicted to be inhibited are colored blue. Benjamini-Hochberg–adjusted P values of less than .05 were considered significant and equivalent to a −log10 P value of 1.3 (indicated by a dashed line). Results were generated by using Ingenuity Pathway Analysis software. B, Biological pathways significantly associated with a food reaction. Weighted gene coexpression network analysis identified 1 module of coexpressed genes that was enriched for differentially expressed genes after a reactive food response. The overrepresented canonical pathways associated with this module are presented. Benjamini-Hochberg (B-H)–adjusted P values of less than .05 were considered significant and equivalent to a −log10 Benjamini-Hochberg P value of 1.3 (indicated by a dashed line). Results were generated by using Ingenuity Pathway Analysis software.
Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci )
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3. Fig 2
Network wiring diagram for the weighted gene coexpression network analysis module associated with a reactive food response. The top 10 hubs within the module network identified as significantly associated with a reactive food response and their first neighbors (based on prior knowledge interactions within the ingenuity knowledge base) are presented. The top 10 hubs are indicated by a boldface outline. The magnitude of upregulation or downregulation for each node is indicated by the intensity of red or green coloring, respectively (log2 fold change in expression between prefood and postfood challenge samples within the reactors group).
Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci )
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4. Fig E1 Molecule legend for Fig 2.
Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci )
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