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Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression 

Published byPrzybysław Marczak Modified over 5 years ago

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Presentation on theme: "Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression "— Presentation transcript:

1 Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression  Jamila Chakir, PhDa, Joanne Shannon, MDb, Sophie Molet, PhDb, Motonori Fukakusa, MDb, Jack Elias, MDc, Michel Laviolette, MDa, Louis-Philippe Boulet, MDa, Qutayba Hamid, MD, PhDb  Journal of Allergy and Clinical Immunology  Volume 111, Issue 6, Pages (June 2003) DOI: /mai Copyright © 2003 Mosby, Inc. Terms and Conditions

2 Fig. 1 Comparison of TGF-β immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

3 Fig. 2 A, Comparison of IL-11 immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). B, Comparison of IL-11 immunoreactivity in the bronchial epithelium of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

4 Fig. 3 A, Comparison of IL-17 immunoreactivity in the bronchial submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). B, Comparison of IL-17 immunoreactivity in the bronchial epithelium of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

5 Fig. 4 Immunoreactivity of type I collagen in the submucosa of control subjects, patients with mild asthma, and patients with moderate-to-severe asthma (before and after the 2-week course of oral corticosteroids). Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2003 Mosby, Inc. Terms and Conditions

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