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Supplemental Fig. 1 A B Cont Ins Gla Det Cont (h) Deg 30 (mU/mL)

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Presentation on theme: "Supplemental Fig. 1 A B Cont Ins Gla Det Cont (h) Deg 30 (mU/mL)"— Presentation transcript:

1 Supplemental Fig. 1 A B Cont Ins Gla Det Cont 12 24 (h) Deg 30 (mU/mL)
pGSK3β GSK3β 3 aa aa aa aa aa aa pGSK3β/GSK3β (fold) 2 a cc 1 Cont 0.03 0.3 3 30 0.03 0.3 3 30 0.03 0.3 3 30 Ins Gla Det (mU/mL) B pAkt Akt aa aa aa 3 pAkt/Akt (fold) 2 1 Cont 12 24 (h) Deg 30 (mU/mL) Supplemental Fig. 1

2 Supplemental Fig. 2 A B pAkt Akt pAkt/Akt (fold) Cont Det HSA HSA+Det
4 aa 3 aa,d pAkt/Akt (fold) 2 1 Cont Det HSA HSA+Det B pAkt Akt 4 aa 3 aa,e pAkt/Akt (fold) 2 1 Cont Deg HSA HSA+Deg Supplemental Fig. 2

3 Supplemental Fig. 3 db/m+ (6 h) db/db (6 h) Hippocampus pAkt pAkt Akt
2 2 pAkt/Akt (fold) pAkt/Akt (fold) 1 1 Cont Ins Gla Det Cont Ins Gla Det Supplemental Fig. 3

4 Supplemental Fig. 4 A B IV injection Glucose (%) Time (min)
120 Cont Ins aa Gla 80 aa Det Glucose (%) aa aa aa aa,bb 40 aa,bb,cc aa,bb,cc 15 30 60 120 Time (min) B ICV injection 150 Cont Ins Gla 100 Det Glucose (%) 50 0.5 2 3 6 Time (h) Supplemental Fig. 4

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