1. The repertoire of NPC-derived cells within the CC during cuprizone-induced demyelination.
The repertoire of NPC-derived cells within the CC during cuprizone-induced demyelination. A, Mediolateral distributions of the total population of YFP+ NPC-derived cells in the rostral, middle, and caudal CC of TAM/cuprizone-challenged Nestin:YFP mice at 2, 3, and 4 weeks of cuprizone challenge. B, Quantification of total YFP+ NPC-derived cells in the CC adjacent to the SVZ revealed a significant recruitment of cells in the rostral and caudal CC starting at 2 weeks of cuprizone challenge, with no significant increase being observed in the middle CC. Two-way ANOVA was used to compare the mean density of YFP+ cells among 2, 3, and 4 weeks of cuprizone challenge for each segment of the CC (**p < 0.01, ****p < ). C, Percentage of YFP+ cells expressing Sox10, GFAP, and/or Dcx in the rostral, middle, and caudal CC of TAM/cuprizone Nestin:YFP mice examined after 4 weeks of cuprizone challenge. D, Plot of the percentage of YFP+ NPC-derived cells that express CC1 or PDGFRα after 4 weeks of cuprizone challenge. Mean ± SEM values are shown.
Yao Lulu Xing et al. J. Neurosci. 2014;34:
©2014 by Society for Neuroscience