1. Phosphoinositide Signaling
Glenn D Prestwich 
Chemistry & Biology 
Volume 11, Issue 5, Pages (May 2004)
DOI: /j.chembiol

2. Figure 1 Chemistry of Phosphoinositide Metabolism (A) PI 3-K reaction.
(B) Interconversions of PIPns by lipid kinases (red) and lipid phosphatases (green). Enzyme abbreviations are defined in the text.
(C) Structures of the phosphatidylinositol polyphosphates and synthetic analogs.
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3. Figure 2
The PI 3-K/Akt Signaling Pathway and Potential Drug Targets for Cancer Therapy
Additional details on therapeutic targets are provided in several reviews [49–51, 55].
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4. Figure 3
Molecular Topologies of Different Tethering Modes for InsPn and PIPn Affinity Probes
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5. Figure 4 Chemistry of Tethered Phosphoinositide Topologies
(A) Comparison of PI(4,5)P2 molecular types attached to a resin, lipophilic BODIPY fluorophore, biotin, benzoyldihydrocinnamoyl (BZDC) photophore, and proxyl spin label.
(B) Preparation of a PI(3,4,5)P3 PolyPIPosome by irradiation of a polymerizable liposome containing a diyne-linked Ins(1,3,4,5)P4 head group.
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6. Figure 5 Immunodetection of Phosphoinositides
KLH, keyhole limpet hemocyanin; EDCI, ethyl N,N-dimethylaminopropylcarbodiimide.
(A) Preparation of an antigenic PI(3,4,5)P3 bioconjugate.
(B) Visualization of PI(3,4,5)P3 in stimulated fibroblasts [171].
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7. Figure 6
Confocal Images Illustrating the Uptake of NBD-PI(3,4)P2 and Texas Red Histone in NIH 3T3 Fibroblasts Using Intracellular Delivery Methods
(A) Sequential optical z-sections (0.2 μm) were collected 5 min after addition of PI(3,4)P2-histone complex. The montage shows six successive 1.5 μm steps from the top of the cell (1) to the attachment of the cell to the substratum (6).
(B) Pseudo-three-dimensional reconstruction. Images are courtesy of J. Shope and D.B. DeWald [107].
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8. Figure 7 Drug Discovery in the PI 3-K Pathway
(A) Fluorescence polarization assay for PI 3-K [114].
(B) Selected inhibitors for PI 3-K [50].
(C) Akt PH domain antagonists [56].
Chemistry & Biology  , DOI: ( /j.chembiol )