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The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities.

Published bySoledad Segura Río Modified over 5 years ago

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Presentation on theme: "The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities."— Presentation transcript:

1 The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities.
The proximal kidney tubule is the target for tenofovir-associated nephrotoxicities. Handling of tenofovir (TFV), the active metabolite of tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide fumarate (TAF), by the proximal tubular cells of the kidney. TFV exits the tubular circulation primarily via the organic anion transporter 1 (OAT1) on the basolateral membrane, and after it is within the cell, it exits into the urine via the apical multidrug resistance protein type 4 (MRP 4) and possibly, MRP 2. TAF is more stable in plasma than TDF, with minimal hydrolyses to TFV. The bulk of TAF is rather transported to target cells. MATE1, multidrug and toxin extrusion transporter 1; OCT2, organic cation transporter 2. Mohamed G. Atta et al. CJASN 2019;14: ©2019 by American Society of Nephrology

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