Presentation is loading. Please wait.

Presentation is loading. Please wait.

Marie Leclerc, Michèle G. Brunette, Denis Couchourel 

Similar presentations


Presentation on theme: "Marie Leclerc, Michèle G. Brunette, Denis Couchourel "— Presentation transcript:

1 Aldosterone enhances renal calcium reabsorption by two types of channels 
Marie Leclerc, Michèle G. Brunette, Denis Couchourel  Kidney International  Volume 66, Issue 1, Pages (July 2004) DOI: /j x Copyright © 2004 International Society of Nephrology Terms and Conditions

2 Figure 1 Effect of 10−8 mol/L aldosterone on 0.5 mmol/L Ca2+ uptake by the distal luminal membrane in the presence(N = 3)and absence(N = 5)of 100 mmol/L Na+.*P < 0.05, **P < 0.01 compared with the control values from untreated tubules, unpaired t test. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

3 Figure 2 Effect of 10−8 mol/L aldosterone on 1 mmol/L Na+ and 0.5 mmol/L Ca2+ uptake by the distal luminal membrane: variation with time of tubule incubation.*P < 0.05, **P < 0.02, ***P < 0.01 compared with the control values, unpaired t test, N = 3. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

4 Figure 3 Effect of 10−8 mol/L aldosterone on 1 mmol/L Na+ and 0.5 mmol/L Ca2+ uptakes by the distal luminal membrane: dose-response curves.*P < 0.05, **P < 0.02, ***P < 0.01 compared with the control values from untreated tubules, unpaired t test, N = 3. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

5 Figure 4 Effect of 10−8 mol/L aldosterone on the Eadie-Hofstee plot of Ca2+ uptake by the distal luminal membrane,N = 3. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

6 Figure 5 Influence of Na+ concentration of the effect of 10−8 mol/L aldosterone on 0.5 mmol/L Ca2+ uptake by the distal luminal membrane.*P < 0.05 compared with the control values from untreated tubules, unpaired t test, N = 5. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

7 Figure 6 Effect of two tyrosine-kinase inhibitors: 5 × 10−5 mol/L AG 18 and 10−6 mol/L genistein on 0.5 mmol/L Ca2+ uptake by membranes from distal tubules treated with 10−8 mol/L aldosterone,N = 3. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions

8 Figure 7 Effect of 1 μmol/L mibefradil, 50 μmol/L diltiazem, or 100 nmol/L ω-conotoxin MVIIC on 0.1 or 0.5 mmol/L Ca2+ uptake by membranes from control or aldosterone treated distal tubules.*P < 0.05, **P < 0.02, ***P < 0.01 compared with the control values from untreated membranes, paired t test; ΔP < 0.05 and ΔΔP < 0.02 compared with the values obtained with untreated membranes, but from tubules incubated with aldosterone, N = 4. Kidney International  , DOI: ( /j x) Copyright © 2004 International Society of Nephrology Terms and Conditions


Download ppt "Marie Leclerc, Michèle G. Brunette, Denis Couchourel "

Similar presentations


Ads by Google