1. Diabetes in Young Adults
A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2
Diabetes in Young Adults
Featured Article:
Richard A. Oram, Kashyap Patel, Anita Hill, Beverley Shields,
Timothy J. McDonald, Angus Jones, Andrew T. Hattersley, and
Michael N. Weedon
Diabetes Care
Volume 39: 337–344
March 2016

2. STUDY OBJECTIVE
To determine whether a score generated from common genetic variants could be used to discriminate between type 1 diabetes (T1D) and type 2 diabetes (T2D) and also to predict severe insulin deficiency in young adults with diabetes
Oram R.A. et al. Diabetes Care 2016;39:337–344

3. STUDY DESIGN AND METHODS
Genetic risk scores (GRSs) from published T1D- and T2D-associated variants were developed
The following was determined:
• Whether the scores could distinguish clinically defined T1D and T2D from the Wellcome Trust Case Control Consortium (WTCCC)
• Whether the T1D GRS correctly classified young adults who progressed to severe insulin deficiency <3 years from diagnosis
Oram R.A. et al. Diabetes Care 2016;39:337–344

4. RESULTS
In the WTCCC, the T1D GRS was highly discriminative of T1D and T2D, and the T2D GRS added little discrimination
A T1D GRS >0.280 is indicative of T1D
A low T1D GRS is indicative of T2D
Most discriminative ability was obtained from just nine single nucleotide polymorphisms
In young adults with diabetes, T1D GRS alone predicted progression to insulin deficiency
T1D GRS, autoantibody status, and clinical features were independent and additive predictors of severe insulin deficiency
Oram R.A. et al. Diabetes Care 2016;39:337–344

5. Oram R.A. et al. Diabetes Care 2016;39:337–344

6. Oram R.A. et al. Diabetes Care 2016;39:337–344

7. Oram R.A. et al. Diabetes Care 2016;39:337–344

8. Oram R.A. et al. Diabetes Care 2016;39:337–344

9. Oram R.A. et al. Diabetes Care 2016;39:337–344

10. CONCLUSIONS
A T1D GRS accurately identifies young adults with diabetes who will require insulin treatment
Oram R.A. et al. Diabetes Care 2016;39:337–344