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Role of neurokinin 3 receptors on responses to colorectal distention in the rat: Electrophysiological and behavioral studies  Véronique Julia*, Xin Su*,

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Presentation on theme: "Role of neurokinin 3 receptors on responses to colorectal distention in the rat: Electrophysiological and behavioral studies  Véronique Julia*, Xin Su*,"— Presentation transcript:

1 Role of neurokinin 3 receptors on responses to colorectal distention in the rat: Electrophysiological and behavioral studies  Véronique Julia*, Xin Su*, Lionel Buéno‡, G.F. Gebhart*  Gastroenterology  Volume 116, Issue 5, Pages (May 1999) DOI: /S (99) Copyright © 1999 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Effect of IP infusion of senktide (5 μg · kg−1 · 30 min−1) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

3 Fig. 1 Effect of IP infusion of senktide (5 μg · kg−1 · 30 min−1) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

4 Fig. 2 Effect of IP administration of SR 142,801 (1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

5 Fig. 2 Effect of IP administration of SR 142,801 (1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

6 Fig. 3 Effect of (A) IP administration of SR 142,801 (3 mg/kg) and (B) ICV administration of senktide (0.5 μg/kg) on the number of colonic spike bursts. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

7 Fig. 4 Effect of ICV administration of senktide (0.05 μg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

8 Fig. 4 Effect of ICV administration of senktide (0.05 μg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

9 Fig. 5 Effect of ICV administration of SR 142,801 (0.1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

10 Fig. 5 Effect of ICV administration of SR 142,801 (0.1 mg/kg) on (A) colonic motility and (B) abdominal contractions produced by CRD. Data are presented as the mean change in the number of spike bursts in response to CRD after drug administration. *Significantly different from corresponding control (0.0 mL; n = 8). Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

11 Fig. 6 Effect of intra-arterial administration of SR 142,801 on pelvic nerve afferent fibers innervating the colon in response to CRD. SR 142,801 was given by cumulative doses (1, 1 + 2, and mg/kg) 5 minutes before the stimulus response function. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

12 Fig. 7 Effect of intra-arterial administration of SR 142,801 on pelvic nerve afferent fibers innervating the urinary bladder in response to UBD. SR 142,801 was given by cumulative doses (1, 1 + 2, and mg/kg) 5 minutes before the stimulus response function. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions


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