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The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children:

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Presentation on theme: "The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children:"— Presentation transcript:

1 The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: A multicenter, double-blind, randomized trial  Sarah Tabbutt, MD, PhD, Susan C. Nicolson, MD, Peter C. Adamson, MD, Xuemei Zhang, MS, Marc L. Hoffman, MD, Winfield Wells, MD, Carl L. Backer, MD, Francis X. McGowan, MD, James S. Tweddell, MD, Paula Bokesch, MD, Mark Schreiner, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 136, Issue 2, Pages (August 2008) DOI: /j.jtcvs Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Flow diagram of patients in whom informed consent was obtained and randomization occurred. BP, Blood pressure. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Concentration time curves for the 125 (circles), 250 (squares), and 500 (triangles) μg · kg−1 · min−1 dose levels. The child age group is shown with dotted lines and gray symbols, and the newborn/infant groups are shown with solid lines and black symbols. Mean ± standard deviation arterial plasma concentrations are shown. Curve fits were derived by using all concentration time point data and not the mean values. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions


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