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Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells.

Published byJacob Berry Modified over 5 years ago

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Presentation on theme: "Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells."— Presentation transcript:

1 Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Interacting MDSCs and mast cells (MC) in human colon carcinoma and in the colon of AOM/DSS-induced tumor-bearing mice. Double immunohistochemistry for CD33 (blue) and tryptase (red) in the human mucosa of a patient with colon carcinoma (A); for IL4R (red) and c-kit (blue) in normal (C) and in dyplastic (D) colonic mucosa of AOM/DSS-induced colon carcinoma–bearing mice; for IL4R (red) and FcεRI (blue) in the spleen of AOM/DSS-treated mouse. Arrows indicate tryptase-positive mast cell interacting with CD33 myeloid cells (in A) and c-kit–positive mast cells interacting with IL4R-expressing lymphocyte (in D), respectively. Original magnification, ×200 (A, left, and C) and ×400 (A, intermediate and right plots, and D). Histograms represent the mean + SD count (in ×400 fields) of interacting MDSCs and mast cells compared with total MCs and MDSCs in at least 4 different samples from patients with human colon carcinoma (B) and AOM/DSS-treated mice (E). Luca Danelli et al. Cancer Immunol Res 2015;3:85-95 ©2015 by American Association for Cancer Research

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