1. Autophagy restrains pancreatic inflammation and expression of pTBK1, CCL5, and PD-L1 in vivo.
Autophagy restrains pancreatic inflammation and expression of pTBK1, CCL5, and PD-L1 in vivo. A, representative low- and high-magnification images of H&E staining of pancreatic tissue obtained from mice with heterozygous Atg5 pancreatic deletion (Atg5L/+) or parallel mice with homozygous Atg5 pancreatic deletion (Atg5L/L) at baseline or on day 1 following cerulein treatment. B, mononuclear inflammatory cell infiltration scoring from three randomly selected areas of each mouse pancreas (×200 magnification). A total of 18 mice, 18 × 3 = 54 spots, were measured; bars show mean ± SEM. P values by the Student t test. C, IHC for S172 pTBK1, CCL5, and PD-L1 in representative sections of Atg5L/+ (top) or Atg5L/L (bottom) mouse pancreatic tissue at baseline. D, IHC for S172 pTBK1, CCL5, and PD-L1 in representative sections of Atg5L/+ (top) or Atg5L/L (bottom) mouse pancreatic tissue on day 1 following cerulein treatment. N.S., not statistically significant.
Shenghong Yang et al. Cancer Immunol Res 2016;4:
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