1. Chapter 7 Antibodies Key Concepts 7.3
• The humoral immune response is mediated by antibodies, which include constant domains as well as variable domains that recognize specific antigens. • Antibody gene rearrangement and hypermutation contribute to antibody diversity.

2. Primary & Secondary Immune Response

3. Immunoglobulin PDBid 1IGT
Antibody Structure
Immunoglobulin PDBid 1IGT

4. Immunoglobulins Differ in Heavy Chain

5. Human Immunoglobulin G (IgG)

6. Immunoglobulin Folds in Light Chain

7. Antigen-Antibody Interaction Met and azidomet hemerythrin PDBid 1HMM

8. Antigen Cross-Linking by Antibodies

9. Box 7-5: Monoclonal Antibodies

10. Box 7-5: Monoclonal Antibodies

11. Box 7-5: Monoclonal Antibodies

12. Antibody-Mediated Autoimmune Diseases

13. Chapter 7 Antibodies Checkpoint 7.3
• Without looking at Fig. 7-39, draw a diagram of an IgG molecule and identify the heavy and light chains, the constant and variable domains, and the antigen-binding site(s). • Explain how a single human can potentially generate billions of different antibody molecules. • What are some factors that might contribute to the development of an autoimmune disease? • Why do the symptoms of an autoimmune disease often differ between individuals?

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