1. The UCLA Clinical and Translational Science Institute
Data and Research Resources
May 9, 2019
Steven Dubinett, MD
Director, UCLA CTSI
Associate Vice Chancellor for Research
▪ bringing CTSI innovations to the greatest health needs in Los Angeles 1

2. UCLA CTSI Partner Institutions
Public research university with leading medical, dental, public health, nursing, engineering, business and life sciences
Cedars-Sinai is the largest nonprofit hospital in the western United States
A private, minority-serving institution located in under-resourced South Los Angeles
Public teaching and research hospital; its catchment area of 3 million residents includes 550,000 below the poverty level
One of the largest health care facilities within the Department of Veterans Affairs with 1.4 million veterans in their service area
In Discussion

3. Bring UCLA CTSI innovations to bear on the
Mission and Vision
MISSION
Bring UCLA CTSI innovations to bear on the
greatest health needs of Los Angeles
and the nation.
VISION
Catalyze research that translates discoveries into tangible improvements
in health care, disease prevention and the health of our community. 3

4. Programs www.ctsi.ucla.edu Informatics
Participant and Clinical Interactions
Community Engagement in Research
Regulatory
Team Science
Special Populations
Workforce Development
Network Resources – Trial Innovation Network
KL2 & TL1 Training Programs
Population Health
Pilot Program
Precision Health
Biostatistics

5. Contact the Informatics Program
Douglas Bell, MD, PhD
Program Leader
Alex Bui, PhD
Program Co-leader
Marianne Zachariah
Program Administrator
Contact the CTSI Informatics Program:

6. Informatics Program Services
Honest Broker Services
Consulting and assistance with:
Clinical Data requests
Complex data bases
Clinical data access
Online, prompted surveys
Terminology systems
Informatics tools
Contact the CTSI Informatics Program:

7. The “Honest Broker” Process for Research
Electronic Health Record
Recruitment Outreach
Data Files
Retrospective Analysis
(with Office of Health Informatics & Analytics and CTSI Biostatistics Program)
-specific data
-specific patients
Since 2013
682 Projects
29 Million Pt Records
The bread and butter of the Informatics Program is the honest broker process, shown on this slide. (This afternoon, Doug Bell will be showing more about how this works, but schematically…)
Researchers who need EHR data get files from us containing the specific data on the specific patients they need. Consultation from our team is indispensable in this because EHR is very complex. We help understand the research question and match it to what’s available.
[CLICK ANIMATION]
2. Researchers can use EHR data for essentially 3 purposes:
Recruitment outreach to people having particular clinical situations, which we can help with
Retrospective analysis, which is a major kind of study we do, in partnership with OHIA and the Biostat program in our own institute, and
Machine Learning, which is a new area that we’re pursuing in conjunction with OHIA, but which we expect will become a major area for innovation in the near future
So far, since 2013, the Informatics Program has provided data through this process for 540 projects, involving a total of 540 million patient records
Machine Learning
(with OHIA, CTSI Biostatistics and Clinical Pathways Program)

8. Tools that Provide Patient Counts – Find Cohorts, Write Grants
i2b2
Implemented at UCLA, Cedars, Harbor
Each site maintains its own data individually
Los Angeles Data Resource (LADR)
Cedars, City of Hope, UCLA, and USC Keck
6.5 million patient records searchable in one system
CHLA and clinics affiliated with Charles Drew are in progress
Accrual to Clinical Trials (ACT)
Search 35 CTSAs across the nation
Available now
Includes UC medical campuses at San Francisco, San Diego, Irvine and Davis
Contact the CTSI Informatics Program:

9. Searches in LADR and ACT
Demographics
Pediatric and adult age ranges
Vital signs
Vital status
ICD-9 and ICD-10 codes
Visit details
CPT codes
Laboratory tests
Medications
Contact the CTSI Informatics Program:

10. COHORT DISCOVERY FEASIBILITY
ACT: The Clinical Research Cycle
STUDY DESIGN
RECRUITMENT
FUNDING
COLLABORATION
ETHICS / COMPLIANCE
COHORT DISCOVERY FEASIBILITY

11. Programs
May 16, AM
Nearly 300 investigators attended training webinars in 2018
Learn how to:
Search 6.5M+ de-identified patient records
Expand a study from single to multi-site
Obtain patient counts from all institutions w/ one query
Inform NIH Inclusion Enrollment Reports w/ patient counts by gender, race and ethnicity
Increase cohort identification for rare disease studies
Obtain coordinated data provisioning support

12. Biostatistics, Epidemiology and Research Design (BERD) Services
David Elashoff, PhD
Program Leader
Website:
Services
Database Consulting
REDCap
Data provisioning consults in collaboration with the Informatics Program
Cloud-based repositories
Infrastructure for clinical trials database
Data Analysis
Grant Collaboration
Study design
Analytic plans
Data management
Trial Design
Bioinformatics
Manuscript preparation

13. Drop-In Biostatistics Consults
Drop-in consults
12-1 PM every Wednesday & 1-3 PM every Friday
Location: 1100 Glendon Avenue, Suite 1820 Los Angeles, CA 90024
Website:
Phone: , Fax:

15. Phase 1 Developmental Therapeutics and Gene Therapy Unit
Initiation and conduct of early-phase clinical pharmacology, investigational device and gene therapy studies in healthy volunteers, special populations (including children) over a spectrum of diseases
Integrated within the UCLA CTSI CTRC
Seamless integration with UCLA investigational pharmacy
Support for:
Intensive PK evaluations/prolonged stays/overnights (i.e. 1,2,4,6,12, 24hr PK draws)
Dose Escalation
Single/multiple dose studies
First-in-human
Bioavailability/Bioequivalence
Drug-drug interaction
Food effect
Thorough QT/QtC

16. CTSI K and Career Development Award Workshop
Date and location
June 13
UCLA Division of General Internal Medicine & Health Services Research
Registration deadline May 23
Go to CTSI website
Space is limited
Speakers
Topic
Carol Mangione, MD, MPH
Navigating the NIH K Award Process
Isidro Salusky, MD
Writing the NIH K Award
Mitchell Wong, MD
UCLA CTSI KL2 Resources
Chris Evans, PhD
Considerations in Applying for a K99

17. Diversity supplements
Grant Library
>350
Current users 75
Total # grants
Grant Mechanism # K 37 R 30 U 3 F 1
Diversity supplements 4

18. CTSI Funding Opportunities
Catalyst Awards
Up to $5K for conferences, seminars and team-building activities
Next round opens July 1
DGSOM Theme Funding, partnered with CTSI and Institute of Precision Health
Two-phase process: Planning grants up to $1K; Seed grants up to $250K
Core Vouchers
Vouchers worth up to $10K for core services at UCLA and CTSI partner institutions, next round spring 2020
Team Science Awards partnered with
Iris Cantor Women’s Health Center
Center for Autism Research and Treatment
Center for AIDS Research – LOI due May 17
Center for Ulcer Research and Education – next round opens fall 2019
Center for Study of Opioid Receptors and Drugs of Abuse (CSORDA) – applications due May 15

19. Contact the Informatics Program
Douglas Bell, MD, PhD
Program Leader
Alex Bui, PhD
Program Co-leader
Marianne Zachariah
Program Administrator
Contact the CTSI Informatics Program: