1. Role of Cathepsin K in the Turnover of the Dermal Extracellular Matrix during Scar Formation 
Thomas M. Rünger, Maria Josefina Quintanilla-Dieck, Jag Bhawan 
Journal of Investigative Dermatology 
Volume 127, Issue 2, Pages (February 2007)
DOI: /sj.jid
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Expression of cathepsin K in surgical scars. Cathepsin K is expressed in cultured human neonatal dermal fibroblasts. (a) Western blot and (b) immune-histochemistry of cells grown on glass slides, showing localization of cathepsin K to the perinuclear endosomal compartment. Bar=20μm.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Expression of cathepsin K in surgical scars. Cathepsin K expression is more prominent in younger scars (1–2.5 months after surgical procedure) than in older scars (4–15 months after surgical procedure). Shown is a representative selection of the 43 scars examined. Bars=100μm for each column of panels.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Strong expression of cathepsin K in a keloid and a dermatofibroma. Panels a and c show a keloid, panels b and d a dermatofibroma. All three keloids examined showed a similar strong cathepsin K expression. Bars=100μm.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
No expression of cathepsin K in the sclerotic areas of morphea. Overview in a, close-up of sclerotic areas in c and d, whereas fibroblasts in the overlying normal dermis (b) show weak expression of cathepsin K (positive internal control). None of the five specimens of morphea examined showed any cathepsin K reactivity in the sclerotic areas. Bars=100μm.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions