1. Adjusted mean±se response in peak forced expiratory volume in 1 s within 3 h post-dosing (peak FEV10–3h) at week 24, following once-daily tiotropium Respimat add-on to high-dose inhaled corticosteroids (ICS) plus a long-acting β2-agonist (LABA) in adults wi...
Adjusted mean±se response in peak forced expiratory volume in 1 s within 3 h post-dosing (peak FEV10–3h) at week 24, following once-daily tiotropium Respimat add-on to high-dose inhaled corticosteroids (ICS) plus a long-acting β2-agonist (LABA) in adults with severe symptomatic asthma, in a) NCT and b) NCT Adjusted for treatment, centre, visit, baseline, treatment-by-visit interaction and baseline-by-visit interaction. Full analysis set. c) Cumulative number of severe exacerbations, over 48 weeks, following once-daily tiotropium Respimat add-on to high-dose ICS plus a LABA in adults with severe symptomatic asthma. Pooled data (NCT and NCT ). Risk reduction of 21% (hazard ratio 0.79, p=0.03). Full analysis set. *: p<0.05; **: p<0.01; ***: p< Reproduced and modified from [58] with permission from the publisher.
William W. Busse et al. Eur Respir Rev 2016;25:54-64
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