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Concomitant blockade of platelet-derived growth factor receptors α and β induces intimal atrophy in baboon PTFE grafts  Michael J Englesbe, MD, Suzanne.

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Presentation on theme: "Concomitant blockade of platelet-derived growth factor receptors α and β induces intimal atrophy in baboon PTFE grafts  Michael J Englesbe, MD, Suzanne."— Presentation transcript:

1 Concomitant blockade of platelet-derived growth factor receptors α and β induces intimal atrophy in baboon PTFE grafts  Michael J Englesbe, MD, Suzanne M Hawkins, BS, Patrick C.H Hsieh, MD, Günter Daum, PhD, Richard D Kenagy, PhD, Alexander W Clowes, MD  Journal of Vascular Surgery  Volume 39, Issue 2, Pages (February 2004) DOI: /j.jvs

2 Fig 1 Intimal area of high-flow (black) and normal-flow (gray) PTFE grafts 2 weeks after initiation of treatment with carrier medium (control) or antibodies to PDGF receptors α or β or to both (*P < .05 vs appropriate flow control). PDGFR, Platelet-derived growth factor receptor. Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 2 Histologic cross sections of normal flow PTFE grafts at 2 weeks after initiation of treatment with vehicle control (A), blocking antibodies to PDGF receptor α (B), blocking antibodies to PDGF receptor β (C), or blocking antibodies to both PDGF receptors α and β (D) (hemotoxylin-eosin, ×16 magnification). Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 3 Apoptotic (% TUNEL positive) cells in the intima of high-flow (black) and normal-flow (gray) PTFE grafts 2 weeks after initiation of treatment with antibodies to PDGF receptor α or β, or to both (*P < .05 vs appropriate flow control).PDGFR, Platelet-derived growth factor receptor. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 4 Proliferating (% BrdU positive) cells in the intima of high-flow (black) and normal-flow (gray) PTFE grafts 2 weeks after initiation of treatment with antibodies to PDGF receptor α or β, or to both (*P < .05 vs appropriate flow control). PDGFR, Platelet-derived growth factor receptor. Journal of Vascular Surgery  , DOI: ( /j.jvs )


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