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Annexin A1 attenuates EMT and metastatic potential in breast cancer

Published byPhebe Lane Modified over 5 years ago

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Presentation on theme: "Annexin A1 attenuates EMT and metastatic potential in breast cancer"— Presentation transcript:

1 Annexin A1 attenuates EMT and metastatic potential in breast cancer
Up‐ or downregulation of E‐cadherin repressors by loss or gain of AnxA1 expression. EpRas‐ and EpC40 cells before and after AnxA1‐RNAi‐induced EMT, and MDA‐MB‐231 human mammary carcinoma cells before and after EMT‐reversal by forced AnxA1expression were processed for quantitative, real‐time RT‐PCR analysis to determine mRNA‐expression levels for five transcription factors repressing E‐cadherin, and Fra‐1 (presumed to act upstream of these factors; I. Custic, unpublished). Results were normalized to GAPDH expression. For details, see Suppl. Exp. Proc. Note: bars in all confocal fluorescence photographs 50 µm. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO Mol Med, Volume: 2, Issue: 10, Pages: , First published: 16 August 2010, DOI: ( /emmm )

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