1. SORCS1 and SORCS3 control energy balance and orexigenic peptide production
The effect of peripheral leptin (2.5 mg/kg body weight) or vehicle (phosphate‐buffered saline, PBS) administration on food intake in 15‐week‐old mice measured over a 24‐h period (n = 8 mice/group). The leptin sensitivity was reduced in S1/3 KO mice. Rectal temperature in 16‐week‐old mice of the indicated genotypes kept at room temperature and after 6 h of cold exposure (4°C) (n = 7–8 mice/group). Cold‐induced thermogenesis is impaired in S1/3 KO mice (two‐way ANOVA, pgenotype = 0.0435). Expression of thermogenic genes in perigonadal adipose tissue from mice after 6‐to 16‐h cold exposure (4°C). Quantitative RT–PCR data are shown as log2‐fold change expression in S1/3 KO relative to the expression in WT (n = 13–14 mice/group). Cold‐induced browning of white adipose tissue is impaired in S1/3 KO as judged by decreased expression of the indicated genes. Ucp1, uncoupling protein 1; Cidea, cell death activator CIDE‐A; Pppargc1a, peroxisome proliferator‐activated receptor γ co‐activator 1‐α; Adrb3, β‐3 adrenergic receptor; Pnpla2, adipose triglyceride lipase; Lipe, hormone‐sensitive lipase. Data information: Data are shown as mean ± SEM and analyzed using a two‐tailed unpaired t‐test (C) or two‐way ANOVA with Bonferroni post‐test (A, B). *P < 0.05.
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EMBO Rep, Volume: 19, Issue: 4, First published: 12 February 2018, DOI: ( /embr )