1. Likelihood of finding unrelated donor or cord blood
Range 98-99%: patients <20 years, when searching for adult donor, then cord blood
Likelihood of finding an unrelated adult donor or cord blood unit on the Be The Match Registry® for a patient <20 years of age, when the search strategy is: 8/8 HLA-matched donor is sought first, then a 7/8 HLA-matched donor, and thereafter a cord-blood unit with an adequate cell dose.
Using human HLA data from the Be The Match Registry, Gragert et al used extensive high-resolution, 4-locus haplotype frequencies to build population-based genetic models for 21 U.S. racial and ethnic groups. For the first time the analysis combines match rates of adult donors and cord blood units and incorporates donor availability, umbilical cord blood unit cell dose, and matching stringency according to currently accepted standards.
New England Journal of Medicine © 2014.  Permission granted to National Marrow Donor Program®/Be The Match® includes rights to provide this chart for one-time presentation or personal use. For publication of this chart (for use in print or web, or repeated presentations), please obtain copyright permissions directly from New England Journal of Medicine.
Gragert L, et al. N Engl J Med. 2014; 371(4):
New England Journal of Medicine © 2014