Presentation is loading. Please wait.

Presentation is loading. Please wait.

MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers

Published byΒλάσιος Παπαφιλίππου Modified over 5 years ago

Similar presentations

Presentation on theme: "MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers"— Presentation transcript:

1 MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers.
MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers. (A) MR1T clone IFN-γ responses to hpMR1+EC or hpMR1+MS tetramers at 7.8 to 500 ng per well. TRBV, TRAJ, and CDR3 sequences are indicated for each MR1T clone. Results are representative of four independent experiments. Error bars represent means and SD from technical replicates. (B) IFN-γ responses from 5 × 105 PBMCs from 15 donors to hpMR1−bac, hpMR1+EC, or hpMR1+MS tetramers, plotted by individual donor (left) or pooled (right). *P < (paired two-tailed t test). Melanie J. Harriff et al. Sci. Immunol. 2018;3:eaao2556 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

Download ppt "MR1Ts respond to microbially derived ligands loaded on hpMR1 tetramers"

Similar presentations

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.
Virus-specific T cell responses are detected in all MERS survivors.

Virus-specific T cell responses are detected in all MERS survivors.
Comparison of repertoire distributions to baseline.

Comparison of repertoire distributions to baseline.
Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.
Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 3 Oil, gas, and FP water variations with time.

Fig. 3 Oil, gas, and FP water variations with time.
Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 Examples of experimental stimuli and behavioral performance.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
Fig. 6 Comparison of properties of water models.

Fig. 6 Comparison of properties of water models.
Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.
Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.

Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique ions. Ligands eluted from hpMR1+EC and hpMR1+MS contain both shared and unique.
GNPS assists in the identification of novel hpMR1 eluted ions.

GNPS assists in the identification of novel hpMR1 eluted ions.
Fig. 2 Reference-fixing experiment, results.

Fig. 2 Reference-fixing experiment, results.
MR1T clones with distinct TCR usage display differential recognition of discrete activating ligands. MR1T clones with distinct TCR usage display differential.

MR1T clones with distinct TCR usage display differential recognition of discrete activating ligands. MR1T clones with distinct TCR usage display differential.
PLI and PLIII are activating ligands for MR1Ts.

PLI and PLIII are activating ligands for MR1Ts.
Fig. 3 IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC cultures. IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC.

Fig. 3 IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC cultures. IT1t blocks TLR7-mediated IFN production of circulating pDCs in PBMC.
Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 3 Glucose- and structure-dependent insulin release.

Similar presentations

Ads by Google