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Social defeat paradigm and prepro-orexin expression in control and defeated rats. Social defeat paradigm and prepro-orexin expression in control and defeated.

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Presentation on theme: "Social defeat paradigm and prepro-orexin expression in control and defeated rats. Social defeat paradigm and prepro-orexin expression in control and defeated."— Presentation transcript:

1 Social defeat paradigm and prepro-orexin expression in control and defeated rats.
Social defeat paradigm and prepro-orexin expression in control and defeated rats. A, Social defeat paradigm. B, Average defeat latency over 7 d of social defeat. Passively coping rats have an average defeat latency <300 s, whereas actively coping rats have an average defeat latency >300 s. C, Prepro-orexin expression in control, passive coping, and active coping rats. Top: representative images of in situ radiolabeling for prepro-orexin in control, passive coping, and active coping rats. Bottom: quantification of in situ radiolabeling in each treatment group reveals that actively coping rats have significantly less prepro-orexin mRNA in the lateral hypothalamus compared with control or passively coping rats. There is a negative correlation between average defeat latency and in situ radiolabeled orexin mRNA. D, Prepro-orexin mRNA expression in control, passive coping, and active coping rats as measured by qPCR. Actively coping rats express significantly less prepro-orexin mRNA than control and passively coping rats. There is a negative correlation between average defeat latency and qPCR-quantified orexin mRNA. *, p < 0.05; **, p < 0.01; ***, p < Laura A. Grafe et al. eNeuro 2018;5:ENEURO ©2018 by Society for Neuroscience

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