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IL1R8 deficiency is associated with increased susceptibility to lymphoma development in lpr mice. IL1R8 deficiency is associated with increased susceptibility.

Published byTorvald Berger Modified over 5 years ago

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Presentation on theme: "IL1R8 deficiency is associated with increased susceptibility to lymphoma development in lpr mice. IL1R8 deficiency is associated with increased susceptibility."— Presentation transcript:

1 IL1R8 deficiency is associated with increased susceptibility to lymphoma development in lpr mice.
IL1R8 deficiency is associated with increased susceptibility to lymphoma development in lpr mice. A and B, Histopathologic analysis of the spleen (A) and lymph nodes (B) of 10- to 12-month-old Il1r8+/+, Il1r8−/−, Il1r8+/+/lpr, and Il1r8−/−/lpr mice stained with H&E (400×; Axioskop 40 microscope equipped with AxioCam MRc camera and AxioVision Rel. 4.8 acquisition software; Zeiss). C and D, Pathologic score of the spleen (C) and lymph nodes (D) of 10- to 12-month-old Il1r8+/+ (n = 2), Il1r8−/− (n = 2), Il1r8+/+/lpr (n = 20), Il1r8−/−/lpr (n = 26) mice (unpaired Student t test; mean and SD are indicated). E, Incidence of DLBCL in Il1r8+/+/lpr (3/23) and Il1r8−/−/lpr (13/26) mice (Fisher test). Federica Riva et al. Cancer Immunol Res 2019;7: ©2019 by American Association for Cancer Research

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