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Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

Published byΆκανθα Νικολάκος Modified over 5 years ago

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Presentation on theme: "Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the."— Presentation transcript:

1 Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the interface with infiltrating immune cells. Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the interface with infiltrating immune cells. At this interface, MCC cells (CK20 immunostain showing a characteristic perinuclear dot-like staining pattern), CD3+ T cells, and associated CD68+ macrophages all showed PD-L1 expression. This pattern was most often observed in geographic foci with a high density of CD8+ T cells. White arrows show lymphocytes expressing PD-L1, and the black arrow shows a PD-L1+ tumor cell cluster immediately adjacent to the immune infiltrate. Original magnification ×400, all panels. Evan J. Lipson et al. Cancer Immunol Res 2013;1:54-63 ©2013 by American Association for Cancer Research

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