1. SMase cleavage sites in sphingomyelin and cellular activities of the reaction products.
SMase cleavage sites in sphingomyelin and cellular activities of the reaction products. SMase Cs cleave SM, generating Cer and phosphorylcholine, while SMase Ds generate Cer-1-phosphate and choline. SMase Ds also have intrinsic lysophospholipase D activities and act on lysophosphatidylcholine to generate the signaling molecule LPA (see also Fig. 5).
Marietta Flores-Díaz et al. Microbiol. Mol. Biol. Rev. 2016; doi: /MMBR