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A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control.

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Presentation on theme: "A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control."— Presentation transcript:

1 A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control. A, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD985, T-DM1, and ADC isotype control. A significant increase in the amount of killing of HER2 0/1+ USC cells was detected when compared with control (P = 0.001) after treatment with SYD985. B, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD995 (T-DM1). No significant increase in the amount of killing of HER2 0/1+ USC cells was detected when compared with control (P = 0.29) after treatment with T-DM1. C, cytotoxicity induced on HER2 3+ USC (ARK-2), HER2 0/1+ USC (ARK-4), and ARK-2/ARK-4 cocultures with 1 μg/mL of SYD989 (isotype control ADC). No significant increase in the amount of killing of HER2 0/1+ USC cells was detected when compared with control (P = 0.51) after treatment with isotype control ADC. Jonathan Black et al. Mol Cancer Ther 2016;15: ©2016 by American Association for Cancer Research

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